Effects of vasodilator stimulated phosphoprotein on intestinal barrier dysfunction after hemorrhagic shock in rats
- VernacularTitle:血管扩张刺激磷蛋白在失血性休克肠屏障功能障碍中的作用
- Author:
Ye ZHANG
;
Jing XU
;
Jiancang LIU
;
Lianyang ZHANG
- Publication Type:Journal Article
- Keywords:
Shock;
Intestinal barrier dysfunction;
Vasodilator stimulated phosphoprotein
- From:
Chinese Journal of Digestive Surgery
2008;7(5):378-379
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of vasedilator stimulated phosphoprotein (VASP) of small intestine mucous membrane on the intestinal barrier dysfunction during hemorrhagic shock (HS) in rats. Methods Forty Wistar rats were divided into normal group, HS 1 hour, HS 2 hours and HS 4 hours groups, as well as HS 2 hours + cyclic adenosine monophosphate (cAMP) treatment group. The activity of sermn diamine oxidase (DAO), content of hematoplasma D-lactic acid of each group were determined, and their relationship with the expression of VASP was analyzed. Results The expression of VASP was increased, serum DAO activity and hematoplasma D-lactic acid content were decreased by cAMP in rats at 2 hours after HS. There were differences upon the levels of VASP expression, DAO activity and hematoplasma D-lactic acid content between HS 2 hours group and HS 2 hours + cAMP treatment group ( t = 18.62, 9.28, 2.83, P < 0.05 ). The serum DAO activity increased while VASP expression decreased significantly after HS, which showed an obvious negative correlation between the two indexes (r=-0.95, P<0.05). Conclusions The decrease of VASP contributes to the intestinal barrier dysfunction after HS in rats, while the intestinal barrier dysfunction can be alleviated by cAMP.
