Systematic review of accuracy of plasma matrix metalloproteinase-9 in predicting hemorrhagic transformation in ischemic stroke
- VernacularTitle:血浆基质金属蛋白酶-9预测缺血性脑卒中出血转化精确度的系统评价
- Author:
Xinhui CAO
;
Ming LIU
;
Bo WU
- Publication Type:Journal Article
- Keywords:
Cerebrovaacular accident;
Cerebral hemorrhage;
Gelatinase B;
Thrombelytic therapy
- From:
Chinese Journal of Neurology
2008;41(10):704-707
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the accuracy of plasma matrix metalloproteinase-9 (MMP-9) predicting hemorrhagic transformation (HT) in ischemic stroke. Methods The studies on plasma MMP-9 predicting HT in ischemic stroke were included, in which diagnostic criteria, methods, and subjects were clearly described, regardless of language of publication and type of studies. MEDLINE (Apr, 1966 to 2006), EMBase (Apt, 1966 to 2006), CNKI (Feb, 1977 to 2006), and wanfangshuju (1989 to 2005) were searched and the references lists of eligible studies were manually searched. Two reviewers independently evaluated the quality of studies and extracted data. The data were analyzed using the Revman 4. 2 or SPSS 11.0. Results Five trials including 497 patients fulfilled the inclusion criteria, 109 of the 497 patients developed HT. The heterogeneity among studies was great (xspecialty 89. 9% (95% CI: 86. 4%-93.5%), sensitivity 86. 5% (95% CI: 77. 3%-96. 8%). Conclusions The values of plasma MMP-9 may be an independent predictor of hemorrhagic transformation. The number of patients in the included studies is not large enough, and the results need to be confirmed in further studies.
