Granulocyte Colony Stimulating Factor for Focal Cerebral Ischemic Injury
- VernacularTitle:粒细胞集落刺激因子治疗局灶性脑缺血性损伤
- Author:
Zhanchuan LIU
;
Changkun WANG
- Publication Type:Journal Article
- Keywords:
granulocyte colony stimulating factor;
cerebral ischemia;
hemopoietic stem cell;
marrow stromal cell
- From:
International Journal of Cerebrovascular Diseases
2008;16(8):600-603
- CountryChina
- Language:Chinese
-
Abstract:
Granulocyte colony stimulating factor(G-CSF)can mobilize hemopoietic stem cells(HSCs)from bone marrow to peripheral circulation,stimulating HSCs and marrow stromal cells(MSCs)homing to the lesion of cerebral ischemia,contributing to the interactions of HSCs and MSCs with the cells in ischemic penumbra,and promoting the generation of neurotrophic factors.G-CSF also has antiapoptotic effect on neurons and drives neurogenesis.Mobilizing autologous HSCs and MSCs using G-CSF for the treatment of local cerebral ischemic injury may reduce the volume of cerebral infarction,and improve neurological functional recovery.
