Research on regional cerebral blood flow in patients of amnestic mild cognitive impairment and vascular cognitive impairment-no dementia
- VernacularTitle:遗忘型轻度认知损害和非痴呆血管性认知损害的局部脑血流量
- Author:
Jing YUAN
;
Jianhui FU
;
Qihao GUO
;
Zhen HONG
- Publication Type:Journal Article
- Keywords:
Congnition disorders;
Memory disorders;
Cerebrovascular accident;
Regional blood flow;
Tomography,X-ray computer
- From:
Chinese Journal of Neurology
2008;41(10):678-682
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the regional cerebral blood flow (rCBF) in amnestic mild cognitive impairment (aMCI) and vascular cognitive impairment-no dementia (VCI-ND) subjects. Methods Sixteen normal elders, 10 patients of aMCI, 12 patients of VCI-ND who were aged from 50 to 80 years old and received an education of middle school or higher. All participants finished cranial CT or MRI. Xe-CT was used to evaluate rCBF of different cerebral regions of all participants. Results The distribution of rCBF of basal ganglia, the cortex and white matter was (76. 4 ± 8. 6), (48.0 ± 7. 1) and (20. 5 ± 1.7) ml· 100 g-1 ·min-1, respectively. When compared in 3 groups, the temporal and parietal lobe rCBF had a decreasing tendency in aMCI group, while in VCI-ND group, the most dominant decreasing parts were mainly concentrated in white matter region ((17. 7±2. 3) ml·100 g-1·min-1, F = 5. 740, P = 0. 002). Whatever the depth or the width was, beth periventricular and subeortical deep white matter, anterior and posterior ventricular regions were all involved. There are no dominant difference of rCBF in caudate nucleus, lentiform nucleus and thalamus. Conclusion The difference in rCBF reflects the pathological difference between aMCI and VCI-ND.
