The relationship between blood homocystei-e concentration in diabetic retinopathy patients and vas-cular endothelial cell damage and platelet activation
- VernacularTitle:糖尿病视网膜病变患者血浆HCY与血管内皮细胞损伤、血小板活化的关系
- Author:
Jing NING
;
Jianbo ZHEN
- Publication Type:Journal Article
- Keywords:
Diabetic retinopathy;
Cysteine;
Endothelial cells;
Platelet activation
- From:
Journal of Chinese Physician
2008;10(8):1048-1050
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analysis the relationship between blood homocysteine concentration in diabetic retinopathy patients with vascular endothelial cell damage and platelet activation.Methods 80 type 2 diabetes mellitus(T2DM)patients,including 50 no diabetic retinopathy(NDR group)and 30 diabetic retinopathy(DR group)and 30 normal controls were selected to measure the concentration of Hcy as well as circulating endothelial cells(CEC),Endothelin(ET),Yon Willebrand(vWF)and platelet activation markers CD62p and CD63.Results The level of CEC,ET,vWF,CD62p,CD63 and Hcy in T2DM group were,distinctly higher than those of control(P＜0.01),furthermore,the level of these markers in DR group were also higher than that in NDR group(P＜0.01).Blood CEC level Was positively related with ET(r=0.839,P＜0.05),and the same relationship was found in Hcy and CEC(r=0.615,P＜0.05),ET(r=0.642,P＜0.05),CD62p(r=0.623,P＜0.05)and CD63(r=0.542,P＜0.05).Conclusions High blood Hcy,CEC,ET,vWF,CD62p and CD63 level were tighdy related with DR.High level of Hcy,vascular endMermis cell damage and platelet activation maybe play an important role in the pathogenesis of DR.
