Submucosal injection of thiotepa for the prevention of recurrence of superficial bladder cancer
- VernacularTitle:黏膜下注射塞替派对非肌层侵犯膀胱癌术后复发的影响
- Author:
Weidong YE
;
Richu LAO
;
Yongxiang SU
- Publication Type:Journal Article
- Keywords:
Bladder neoplasms;
Drug therapy;
Antineoplastic combined chemotherapy proto-cols;
Neoplasm recurrence,local
- From:
Chinese Journal of Postgraduates of Medicine
2008;31(29):20-23
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the efficacy of submucosal injection of thiotepa for the prevention of recurrence of superficial bladder cancer. Methods Sixty-six patients with superficial bladder cancer were chosen, they were randomly divided into injection group(33 cases)and control group(33 cases). In injection group, 33 patients had submucosal injection of thiotepa, after 30 minutes resection of bladder tumor were treated by PKRBt, after one week, they were given perfusion 27 mg BCG. In control group, 33 patients after the PKRBt were given perfusion BCG. Results The recurrence rate in injection group was 15.2%, and that of the control group was 27.3%. There was significant difference between the twO group (P<0.05). Con-clusions The submucosal injection of thiotepa , PKRBt and perfusion BCG could prevent tumor recur-rence,it has the following advantage,such as simple , safe, less side effect ,more economical. The submu-cosal injection is a practical method to prevent tumor recurrence and is worth popularizing.
