Influence of jiaweibugan decoction on VEGF expression of sciatic nerve in experimental diabetic rats
- VernacularTitle:加味补肝汤对糖尿病大鼠坐骨神经中VEGF表达的影响
- Author:
Jianyu FU
;
Zeqi CHEN
;
Juan HUANG
;
Lili XIONG
;
Xingping DAI
- Publication Type:Journal Article
- Keywords:
Beinforcing liver & kidney;
Diabetic neuropathies/ZD;
Sciatic nerve;
Vascular endothelial growth factors
- From:
Journal of Chinese Physician
2008;10(8):1028-1031
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of jiaweibugan decoction on VEGF expression of sciatic nerve in experimental diabetic rat and explore the preventive and therapeutic effects of iiaweibugan decoction on peripheral neumpathy in~xperimental diabetic rats.Methotis The diabetic rat model was established by streptozotocin(STZ).The rats were killed on the 4th or 8th week from the beginning of treatment respectively,and VEGF mRNA of sciatic nerve was detected by reverse-transcriptase polymerase chain reaction(RT-PCR).Resuits The results of RT-PCR showed that VEGF expression ofthe model group and treated group on the4th or8th week WaS higherthan that of the normal control group(P＜0.05).Compared with the model group,VEGF expression in the diabetic rats treated byjiaweibugan decoction increased markedly at the end of4th week(P＜0.05),while decreaSed significantly at the end of8th week(P＜0.05).Conclusion Jiaweibugan decoction has a proventive and therapeutic effect on peripheral neumpathy in experimental diabetic rats.
