Effect of sperm factor on recurrent pregnancy loss
- VernacularTitle:精子因素对反复自然流产的影响
- Author:
Zhigang DING
;
Hongchuan NIE
;
Wenbing ZHU
;
Guangxiu LU
;
Liqing FAN
- Publication Type:Journal Article
- Keywords:
Spermatoza;
Abortion,spontaneous/ET;
Abortion,habitual/ET
- From:
Journal of Chinese Physician
2008;10(8):1045-1047
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the effect of sperm factor on recurrent pregnancy lass.Methods Accordingto WHO criteria,we routinely analyzed the sperm of 21 unexplained recurrent pregnancy loss patients as study group.and 20 proven fertility men as control group.Meanwhile,we evaluated sperm chromosome aneuploidy for chromosomes 18,X and Y using standard FISH procedure,and sperm DNA ingegrity using sperm chromatin structure assay(SCSA)procedure.Results The percentage of normal morphology sperm is(10.8±2.8)%,and DFI value is(21.7±6.7)%,and the percentage of sperm aneuploidy for sex chromosome and chromosome 18 is(0.80±0.14)%and(0.23 ±0.09)%respectivelyin study group.The differences between the two groups were statistically significant(P＜0.01).Conclusion Sperm morphology,DNA integrity and chromosome aneuploidy are the correlative factors to recurrent pregnancy loss.
