Effect of IL-2 to dendritic cell in chronic hepatitis B
- VernacularTitle:白介素-2对慢性乙肝患者外周树突状细胞的影响
- Author:
Hongxun ZHU
;
Mingsheng LEI
- Publication Type:Journal Article
- Keywords:
Interleukin-2;
Hepatitis B,chronic;
Dendritic cells
- From:
Journal of Chinese Physician
2008;10(8):1066-1068
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the role of IL-2 dendritic cell in chronic hepatitis B,peri-dendritic cells were cultured,cytokins CD4O,CD86,CD80,CD83 and IL-2 were measured by ELLISA.Methods 20 chronic hepatitis B patients were selected,each one donated 15ml blood.dentritic cells were cultured,and IL-4 1000u/ml rhGM-CSF 1000u/ml was given each well,while IL-2 100u/ml was given each control well.CD40,CD86,CD80 and CD83 were measured by FLSC at 9th day.IL-2 was detected by ELISA at 12th day.Results The level of CD40,CD86,CD80 and CD83 in increased when using IL-2,and dentritic cell secreted IL-2 in chronic hepatitis.Conclusion The results suggest that IL-2 can promote the phenotypic and functional maturation of PC.
