Studies of type 1 diabetic mice models indued by MLD-STZ
- VernacularTitle:链脲佐菌素诱导1型糖尿病小鼠模型的研究
- Author:
Lixin ZHANG
;
Xingyu PAN
- Publication Type:Journal Article
- Keywords:
Streptozotocin;
Type 1 diabetes mellitus;
Mice;
Animal model
- From:
Chinese Journal of Primary Medicine and Pharmacy
2008;15(8):1324-1325
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the characteristics of type 1 diabetic mice models induced by multiple low dcee streptozotoein(MLD-STZ).Methods Type 1 diabetic mice models was induced with intraperitoneally injection of STZ(40mg/kg body weight,daily)for 5 consecutive days and detected fasting blood glucose,urine glucose and histological ehange of panereata.Results The incidence of type 1 diabetes mdlitus was 65%;compared with normal control group,blood glucose and urine glucose levels increased significantly and histological analysis of pancreata showed marked insulitis in diabetic model group,and the hyperglycemia maintained from the fourth to the eighth week after the firml STZ injection.Conelnsion Type 1 diabetie mice models could be made successfully by MLDSTZ,and the hyperglycemia could maintain for a rather long time.
