Effects of rizatriptan on cortical spreading depression and c-Fos expression within periaqueductal grey
- VernacularTitle:苯甲酸利扎曲普坦对皮质扩布性抑制及中脑导水管周围灰质c-Fos表达的影响
- Author:
Fengpeng LI
;
Shengyuan YU
;
Weiping GUAN
;
Hong SHI
;
Shuli CHEN
;
Zhigao JIN
;
Shiwen WU
;
Zhao DONG
;
Enchao QIU
;
Ruozhuo LIU
;
Lei JIANG
- Publication Type:Journal Article
- Keywords:
Periaqueductal gray;
Triazoles;
Cerebral cortex;
Proto-oncogene proteins c-fos;
Genes,fos
- From:
Chinese Journal of Neurology
2008;41(9):624-627
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine whether rizatriptan has an effect on cortical spreading depression (CSD) and c-Fos expression within periaqueductal grey (PAG) induced by CSD in rats. Methods The experimental SD rats were randomly divided into group A injected with KCl, group B KCl plus rizatriptan and group C NaCL The number and amplitude of CSD were recorded after KCl or NaCl injection. C-Fos positive neurons of different layer were identified by the immunohistochemical technique 2 hours after the first injection of KCl or NaCl. Results There was no CSD in group C. The number of CSD in group A ( 10.70±3.23 ) was significantly more than that in group B (6.10±2.56, t = - 3.528, P < 0.01 ). The amplitude of CSD in group A ( 17.33 (95% CI 11.45--23.11 ) mV) was significantly greater than that in group B (11.82 (95%CI 9.24--14.70) mV, Z= -4.360, P< 0.01). There were more cFos-like immnoreactive neurons in every layer in group A than in group C (P < 0.01 ) and in group B (P < 0.05 ). Conclusion Rizatriptan has an inhibitory effect on CSD, which might induce the headache through exciting the neurons in PAG.
