Correlation of KAI1/CD82 and laminin receptor in cholangiocarcinoma
- VernacularTitle:胆管癌组织中KAI1/CD82和层黏素受体的关系
- Author:
Xiaoming DENG
;
Shuguang WANG
;
Zhanfeng GAO
;
Tianyu LI
;
Weiwei JIANG
- Publication Type:Journal Article
- Keywords:
KAI1/CD82;
Laminin receptor;
Cholangiocarcinoma;
Metastasis
- From:
Chinese Journal of Digestive Surgery
2008;7(5):366-368
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation of the expression of KAI1/CD82 and laminin receptor (LNR) in cholangiocarcinoma, and study its role in the invasion and metastasis of cholangiocarcinoma. Methods The expressions of KAI1/CD82 and LNR in 48 cholangiocarcinoma tissue samples were detected by SP immunohistochemistry, and their relationships with clinicopathological factors were analyzed. Results The positive expression rates of KAI1/CD82 and LNR in cholangiocarcinoma were 31% (15/48) and 54% (26/48), respectively. In highly differentiated cholangiocarcinoma, the positive expression rate of KAI1/CD82 was high (χ2=3.911, P<0.05), while that of the LNR was low (χ2=6.970, P<0.05). The positive expression rate of KAI1/CD82 in cholangiocarcinoma with metastasis was significantly lower than that in cholangiocarcinoma without metastasis (χ2=5.765, P<0.05), while the positive expression rate of LNR in cholangiocarcinoma with metastasis was significantly higher than that in cholangiocarcinoma without metastasis (χ2= 9.952, P<0.05). The expression level of KAI1/CD82 was negatively correlated with that of the LNR ( r = -0.462, P < 0.01 ). Conclusions The up-regulated expression of LNR in cholangiocarcinoma correlates with the decreased expression of KAI1/CD82, and plays an important role in the invasion and metastasis of cholangio-carcinoma.
