Polymorphisms Val762Ala in PARP-1 and gastric cancer
- VernacularTitle:多聚ADP核糖聚合酶1Val762Ala基因多态性与胃癌易感性的关系
- Author:
Quanbao ZHANG
;
Yumin LI
;
Xun LI
;
Wence ZHOU
;
Bin SHI
;
Hao CHEN
;
Wenzhen YUAN
- Publication Type:Journal Article
- Keywords:
Stomach neoplasms;
Polymorphism,restriction fragment length;
Poly(ADPribose) polymerases;
Genetic predisposition to disease
- From:
Chinese Journal of General Surgery
2008;23(9):706-709
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the frequency distribution of Val762Ala(T2444C)polymorphism among Han Chinese population in Gansu province,and to explore its relation to the suseeptibihty to gastric cancer. Methods A hospital-based,case-control study was performed involving 138 patients with gastric cancer and 110 healthy controls by PCR-RFLP method.Logistic regression and Chisquare analyses were used to assess OR and 95% CI. Results PARP-1762Ala allele was overexpressed in gastric cancer cases(11.5%)compared with controls(4.5%)(OR=3.012,95%CI 1.054-8.603,P=0.033).Statistic analysis showed increaged risk for gastric cancer patients with the 762Ala allele.Conclusion PARP-1 Val762Ala(T2444C)is related to the risk of gastric cancer,PARP-1762Ala allele could be used as a susceptibility marker for the development of gastric cancer.
