A clinical observation of single doxepin or trimebutine mealate and combination of them in the treatment of irritable bowel syndrome
- VernacularTitle:多塞平与马来酸曲美布汀单用或联用治疗肠易激综合征的临床观察
- Author:
Jingdong WANG
- Publication Type:Journal Article
- Keywords:
Rritable bowel syndrome;
Doxepin;
Trimebutine
- From:
Chinese Journal of General Practitioners
2008;7(9):632-635
- CountryChina
- Language:Chinese
-
Abstract:
193 patients with irritable bowel syndrome (IBS) were divided into 3 groups stochastically:73 cases were treated with both trimebutine malate and doxepin. 56 cases were only treated with doxepin, and this group was given doxepin to take orally. The other 64 cases were only treated with trimebutine malate. This group were given trimebutine malate to take orally. Doxepin was given 12.5-25.0 mg tid po, and trimebutine malate was given 200 mg tid po. This is for a course of 4-week-therapy. The rates of the total response of the 3 groups were 95.9%, 83.9% and 81.3% respaefively. The effect of the combination of the 2 drugs is much higher than the other two (P<0.01), and especially it has the highest effect on diarrhea type IBS. The rates of the improvement of nervos and mental symptoms were 87.0%, 79.0% and 71.6% respectively. The effect of combination use is the highest. It suggests that both the single use and combination use of doxepin and trimebutine malate has the effect on the treatment of IBS, but the combination use can improve the effect obviously.
