Cliaical study of altering immunity for Chuanxiongqin ulinastain and thymosin α1 on sepsis patients
- VernacularTitle:川芎嗪、乌司他丁和胸腺肽α1对脓毒症患者的免疫调理作用
- Author:
Yong PAN
;
Jie XV
;
Lanzhi ZHAO
;
Bin ZHANG
;
Yinjie CHEN
;
Qiusheng XIAO
;
Xiu QIN
- Publication Type:Journal Article
- Keywords:
Chuanxiongqin;
Ulinastain and thymeain α1;
Sepsis;
Immunity
- From:
Chinese Journal of Primary Medicine and Pharmacy
2008;15(8):1263-1264
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of microcireulation blood flow and altering immunity by Chuanxiongqin,ulinastain and thymosin α1 on sepsis patients.Methods 90 patients were randomly divided into 3 groups(n=30),namely ICU group,Chuanxiongqin group,ulinastain and thymosin α1 group.HLA-DR/CD14+and IL-6,TNF-α,Lac,DD were measured.Results (1)DD showed no significant difference at every time point between ICU group and ulinastain+thymosin α1 group(P＞0.05).DD decreased in Chuanxiongqin group,and was significantly different from the others on the third day.(2)Lac unchanged significantly at every time point in ICU group(P＞0.05).Lac in Chuanxiongqin group and ulinastain+thymeain α1 group tended to decrease,and was statistically different from ICU group on the second day.(3)IL-6 and TNF-α tended to increase at every time point in ICU group(P＜0.05).In ulinastain+thymosin α1 group,IL-6 and TNF-α returned to the level before treatment,HLA-DR/(D14+increased significantly,and was higher than Chuanxiongqin group and ICU group statistically.Conclusion Chuanxiongqin could ameliorate circulation;ulinastsin and thymosin α1 could depress IL-6,TNF-α.So ulinastain and thymosin α1 might protect the immunity of sepsis patients.
