Evaluation on angiogenesis of breast carcinoma and precancerous lesion with power Doppler imaging and contrast enhanced microvascular imaging
- VernacularTitle:能量多普勒及超声造影微血管成像对乳腺癌及癌前病变微血管生长变化的评价
- Author:
Yingjia LI
;
Yunkun ZHANG
;
Fenglin WU
- Publication Type:Journal Article
- Keywords:
Ultrasonography;
Microbubbles;
Breast neoplasms
- From:
Chinese Journal of Ultrasonography
2008;17(9):785-788
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the angiogenesis characteristics of normal breast,simple hyperplasia,atypical hyperplasia,intraductal carcinoma in situ and invasive ductal carcinoma.Methods Twenty cases in normal controls,20 cases with simple hyperplasia,20 cases with atypical hyperplasia,20 cases with intraductal carcinoma in situ and 30 cases with invasive ductal carcinoma were inspected with power Doppler imaging(PDI)and contrast enhanced microvascular imaging(MVI)on the quantity,configuration and distribution of angiogenesis.The microvessel density(MVD)were detected by immunohistochemical technique.ResultsWith the progression of breast cancer,MVD and grades of PDI kept increasing.Meanwhile,the blood vessels became twisted and increased in quantity with expansion into the lesion,the configuration of blood vessels became disordered.However,the changes mentioned above were not obvious in the very early stages.they became significant from the atypical hyperplasia(AH)stage.Conclusions Contrast MVI and PDI may be useful to screen high risk population with high risk of breast cancer due to their detection of changes in angiogenesis of breast carcinoma and precancerous lesions.
