Expression of latent transforming growth factor beta binding protein-1 and transforming growth factor beta type Ⅱ receptor in condyloma acuminatum tissues
- VernacularTitle:尖锐湿疣组织LTBP-1和TGF-βRⅡ的表达
- Author:
Yong HU
;
Qing GUO
;
Fanqin ZENG
;
Zengqi TANG
;
Yanhui LIN
;
Hongfeng TANG
- Publication Type:Journal Article
- Keywords:
Condyloma acuminatum;
Transforming growth factor beta;
Latent TGF-beta binding proteins;
Receptor,transforming growth factors
- From:
Chinese Journal of Dermatology
2008;41(10):677-679
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the role of the expression of latent transforming growth factor beta binding protein-1 (LTBP-1) and transforming growth factor beta receptor type Ⅱ(TGF-beta R Ⅱ) in the pathogenesis of condyloma acuminatum (CA). Methods Samples were resected from the lesions of 30 patients with CA and prepuces of 17 normal human controls. The mRNA and protein expressions of LTBP-1 and TGF-betaR Ⅱ were assessed by quantitative real-time PCR and a streptavidin-biotin-peroxidase staining technique, respectively. Results As shown by Real time PCR, the mRNA expression levels of LTBP-1 and TGF-betaR Ⅱ were significantly higher in CA tissues than those in the controls, with the average value of 2 (-Delta Delta α) being 2.46 and 3.43, respectively. A lower intensity of stainning was observed for LTBP-1 and TGF-betaR Ⅱ in CA tissues compared with the normal controls (182.51±9.89 vs 167.78±12.56, 187.35± 11.23 vs 170.15±13.21, t = 5.62, 3.70 respectively, both P <0.01). Conclusion The decrease in the expres-sion of both LTBP-1 and TGF-betaR Ⅱ may lead to the abnormality in the activation of TGF-beta and signal transduction pathways.
