The experimental study on the evaluation of liver fibrosis using contrast enhanced sonography
- VernacularTitle:超声造影评价肝纤维化的实验研究
- Author:
Limei XIE
;
Qiyong GUO
;
Xin LIU
;
Guifeng ZHAO
;
Lian JI
- Publication Type:Journal Article
- Keywords:
Ultrasonography;
Microbubbles;
Liver cirrhosis
- From:
Chinese Journal of Ultrasonography
2008;17(9):809-812
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the value of evaluating rat liver fibrosis using contrast enhanced sonography.Methods Carbon tetrachloride was used to induce liver fibrosis.Under the mode of pulse-inversion harmonic imaging,ultrasound contrast agent was bolus iniected through tail vein,hepatic artery arrival time(HAAT),portal vein arrival time(PVAT),hepatic vein arrival time(HVAT)was recorded,and their relationship with immunohistochemical results were analyzed.Results There was no statistical difference of HAAT,PVAT between two groups among S0-S4 stage.HVAT was shorter in S3 and S4 stage than in S0-S2 stage(P＜0.05).HVAT was negative correlated with the percentage of immunohistochemical positive area of C-Ⅳ,LN,the correlation coefficients were-0.680 and -0.639 respectively.Conclusions Contrast enhanced sonography is useful for the diagnosing liver fibrosis.
