Clinicopathologic features, diagnosis and treatment of pancreatic mucinons noncystic adenocarcinoma
- VernacularTitle:胰腺黏液非囊性癌的临床病理特点及诊治体会
- Author:
Hui QU
;
Yuemin SUN
;
Chengfeng WANG
;
Yi SHAN
;
Dongbing ZHAO
;
Guohua DENG
;
Ping ZHAO
- Publication Type:Journal Article
- Keywords:
Pancreatic neoplasms;
Diagnosis;
Therapy;
Prognosis;
Mucinous noncysticadenocarcinoma
- From:
Chinese Journal of General Surgery
2008;23(10):750-752
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinicopathological features, diagnosis and therapy for pancreatic mutinous noncystic adenocareinoma(MNAC). Methods Eleven MNAC cases treated in our hospital were studied retrospectively. The clinical and pathologic data were reviewed. Results Of the 11 patients, 6 were male and 5 were female. The age ranged from 47 to 76 years with average of 60. 5 years.The main complains included upper abdominal discomfort in 8 cases, abdominal mass in 1 case and jaundice in 2 cases. CA199 serum test was positive in all patients and 5-fold high above normal value in 6 cases. The preoperative radiography of MNAC was usually not specific. Tumors located in the head in 5 cases and in the body and tail of the pancreas in 6 cases. The diameter of the tumor was 4 - 11 cm with average of 6. 5 cm.All cases underwent operation, with radical resection in 2 cases. Liver or abdominal metastasis was found in 5 cases. Postoperative immunohistochemistry showed that MUC-1 was negative in all patients. MUC-2,PCNA and Ki-67 were positive in all patients. All 9 cases that were followed-up died within 5 -22 months,with an average survival time of 10 months. Conclusions The diagnosis of MNAC depends on pathology. Its prognosis is poor.
