Study on the antioxidative capability and Na+-K+-ATPase α1-subunit mRNA expression in myocardinm of hypothyroid rats
- VernacularTitle:甲状腺功能减退大鼠心肌抗氧化能力及Na+-K+-ATP酶α1亚基mRNA表达的研究
- Author:
Hui FANG
;
Yumei PEI
;
Yazhong ZHANG
;
Jinli TIAN
;
Jingxia FANG
;
Hewei ZHANG
;
Jing XU
;
Weiping WU
- Publication Type:Journal Article
- Keywords:
Hypothyroidism;
Peroxidative damage;
Heart;
Na+-K+-exchanging ATPase
- From:
Chinese Journal of Endocrinology and Metabolism
2008;24(5):550-551
- CountryChina
- Language:Chinese
-
Abstract:
The antioxidative capability and Na+-K+-ATPase α1-subunit mRNA expression in myocardium of hypothyroid rats induced by low-iodine diet were observed. The results showed that the antioxidative capability of myocardium decreased, resulting in lipid peroxidative damage, atrophy of myocardial cells and chondrification of tunica intima, along with decreased expression of sodium pump α1 subunit mRNA in hypothyroid rats.
