Cutaneous dendritic ceil-derived non-Langerhans cell histiocytosis: a new entity?
- VernacularTitle:皮肤非朗格汉斯树突细胞组织细胞增生症:一个新病种?
- Author:
Lin NONG
;
Yi ZHAO
;
Yali REN
;
Ping TU
;
Yan XIONG
;
Shuang ZHANG
;
Xuejun ZHU
;
Ting LI
- Publication Type:Journal Article
- Keywords:
Skin;
Dendritic cells;
Histiocytosis
- From:
Chinese Journal of Dermatology
2008;41(10):653-656
- CountryChina
- Language:Chinese
-
Abstract:
A 57-year-old man was admitted to the hospital for a 7-year progressively spreading plaques involving the entire body surface, and multiple irregularly sized red nodules and infiltrated patches on the face, trunk and limbs. Histopathological examination showed pleomorphic tumor cells diffusely dis-persed throughout the dennis, giving an appearance of low proliferation. Some cells with cytoplasmic pro-cesses appeared multiangular in shape, lmmunohistochemically, tumor cells were negative for CDla or S-100, but positive for CD45, FXIIIa, CDl4, MHC- Ⅱ, CD68 and lysozyme with extracellular interstitial expression. Ultrastructurally, the cells exhibited cytoplasmic processes and irregularly sized nuclei; no Birbeck granules were observed. Vesicules of low electron-density were seen diffusely in cytoplasm and extracellular matrix. The case is herein diagnosed as cutaneous non-Langerhans cell histiocytosis, which presents with a chronically invasive clinical course. These cells may develop from immature dermal dendritic cells.
