Association of HLA-Cw alleles with systemic lupus erythematosus
- VernacularTitle:系统性红斑狼疮与人类白细胞抗原-Cw基因相关性的研究
- Author:
Hongsheng SUN
;
Yanfeng HOU
;
Yuanchao ZHANG
;
Yulian JIAO
;
Qingrui YANG
;
Guangzhi SUN
;
Yueran ZHAO
- Publication Type:Journal Article
- Keywords:
Lupus erythematesus,systemic;
HLA antigens;
Alleles
- From:
Chinese Journal of Rheumatology
2008;12(10):667-669
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the association between HLA-Cw alleles with systemic lupuserythematosus. Methods Polymerase chain reaction-sequence specific primer method was used to analyze thedistribution of HLA-Cw01-08 alleles among 108 patients with SLE and 102 healthy controls. The allelefrequencies was compared between various patient groups and the control population. Results The frequencyof HLA-Cw07 alleles in patients with SLE was significantly increased in patients with SLE. Conclusion Theresults indicate that HLA-Cw07 may be the susceptible alleles or may be closely linked to the susceptiblegenes for SLE.
