Influence of escin on the renal function of BXSB mice
- VernacularTitle:七叶皂苷对BXSB狼疮小鼠肾功能的影响
- Author:
Yongji LI
;
Anbin HUANG
;
Xingruo ZENG
- Publication Type:Journal Article
- Keywords:
Escuhn aesculin;
Lupus erythmatosus,systemic;
Mice
- From:
Chinese Journal of Rheumatology
2008;12(10):690-692
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of escin on proteinuria and renal function of BXSB mice. Methods BXSB mice were divided randomly into group A (control group), B (steroid treatment group), C(steroid combined with high-dose esein treatment group) and D (streroid combined with low-doze escin group). The proteinufia and renal function were detected by albustix and automatic biochemistry analyzer after a month's treatment. Results Group C reduced the level of proteinuria and parameters of renal function (BUN and Cr) significantly when compared with other three groups (P<0.05). Conclusion Escin can reduce the level of proteinuria and protect renal function of BXSB mice.
