Histopathological study of atypical hyperplastic thyroid epithelial cells in Hashimoto's thyroiditis
- VernacularTitle:桥本甲状腺炎不典型增生甲状腺上皮细胞的组织病理学研究
- Author:
Baoyan ZHANG
;
Rujun XU
;
Lihong CHEN
;
Jinquan WANG
;
Haihong CUI
;
Guoying SUN
;
Yiping ZHOU
- Publication Type:Journal Article
- Keywords:
Hashimoto's thyroiditis;
Thyroid neoplasms;
Carcinoma,papillary;
Immunohistochemistry;
CK19;
PCNA;
Bel-2
- From:
Chinese Journal of Endocrinology and Metabolism
2008;24(5):509-512
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore histopathological features of the atypical hyperplastie thyroid epithelial cells (TEC) in Hashimoto's thyroiditis (HT), and to investigate its association with papillary thyroid carcinoma (PTC). Methods Thirty cases of HT with atypical hyperplastie TEC and 50 cases of PTC were selected from archives, the comparatively normal follicles around thyroid adenoma and in HT served as eontroi group. The morphological changes in HT were observed and the expressions of CK19. PCNA, Bcl-2 were detected by Max-Vision immunohistochemistry techniques. The results were analyzed by Chi-square test. Results The atypical hyperplastic TEC in HT showed some PTC-like features such as crowded cells, nucleus enlargement and ground glass appearance in the nucleus. As compared to the control, CKI9, PCNA and Bcl-2 were positively expressed in both atypical hyperplastic TEC in HT and PTC cells (P<0.05). Conclusion The atypical hyperplastic TEC in HT showed some morphological and immunological features of PTC, with the PTC specific marker CK19 expression,suggesting that the atypical hyperplastic TEC in HT may link HT with PTC, leading to malignant transformation,which should be closely watched.
