Investigation of the plasma cortisol and the function of hypothalamic-pituitary-adrenal axis in type 2 diabetic patients
- VernacularTitle:2型糖尿病患者皮质醇水平及下丘脑-垂体-肾上腺轴活性
- Author:
Lihua WANG
;
Wei LIU
;
Shengxian LI
;
Rong HUANG
;
Qi CHENG
;
Yihua WU
- Publication Type:Journal Article
- Keywords:
Diabetes meUitua,type 2;
Cortisol;
Hypothalamic-pituitary-adrenal axis
- From:
Chinese Journal of Endocrinology and Metabolism
2008;24(5):525-526
- CountryChina
- Language:Chinese
-
Abstract:
The plasma level and the regulation of cortisol in type 2 diabetic patients were invesligated.Plasma and urinary cortisol levels were measured, and dexamethasonc suppression test and oral cortisone test in vivo were performed. Compared with controls, diabetic patients had higher urinary cortisol level. The activity of hepatic 11 β-hydroxy-steroid dehydrogenase-1 (11β-HSD1) in type 2 diabetic patients was decreased, suggesting that the elevated basal cortisol in type 2 diabetic patiens may due to impaired hepatic degradation of cortisol.
