A swine model of cardiac arrest produced by programmed electrical stimulation
- VernacularTitle:应用程控刺激的心脏骤停模型
- Author:
Junyuan WU
;
Chunsheng LI
- Publication Type:Journal Article
- Keywords:
Programmed electrical stimulation;
Cardiac arrest;
Ventricular fibrillation;
Swine
- From:
Chinese Journal of Emergency Medicine
2008;17(10):1063-1065
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish a stabile normal model of cardiac arrest (CA) by programmed electrical stimulation(PES). Method Eighteen healthy domestic swine were anesthesiased with propofol. Ventrieular fibril-lation (VF) was induced by PES through right ventricle after tracheal intubation. The PES mode is S1S2 (300/200 ms), 40 V, and-10 ms step length. Results VF was successfully induced in 16 of eighteen swine with the method of PES. The extent of coupling interval of S1S2 was between 110 and 190 ms (168±23) ms. VF occurred in 2 swines when S1S1 (350 ms) stimulus was used to decide if the electrede was placed in right ventricle. All the swine were successfully defibrillated after 3 minutes of untreated VF. Conclusions This swine model of VF is easy to repeat and orerase, and has little injury on the heart. Therefore PES is a good method to make animal car-diac arrest model.
