Significance of Bcl-2 family in tumor progression and therapy
- VernacularTitle:Bcl-2家族在肿瘤进展和治疗中的意义
- Author:
Yuanyuan ZHU
- Publication Type:Journal Article
- Keywords:
Genes,bcl-2;
Neoplasms;
Apoptosis
- From:
Journal of International Oncology
2008;35(10):726-728
- CountryChina
- Language:Chinese
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Abstract:
Bcl-2 family have dual-regulating effects on cell apoptosis mediated by mitoehondrion. The ratio of pro-apoptosis members and anti-apoptosis members closely correlates with tumorigenesis, drug-resist-ance and prognosis. Therefore,Bcl-2 family become important targets in tumor biotherapy. Many strategies have been applied to tumors treatment targeting Bcl-2 family,such as some biological treatment,short peptides and organic small molecules.
