Glucosylceramide synthase in tumor multidrug- resistance
- VernacularTitle:葡萄糖神经酰胺合成酶在肿瘤多药耐药中的研究
- Author:
Li YIN
- Publication Type:Journal Article
- Keywords:
Glueosyltransferases;
Drug resistance,neoplasm;
Ceramides
- From:
Journal of International Oncology
2008;35(10):732-735
- CountryChina
- Language:Chinese
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Abstract:
Glucosylceramide synthase(GCS) plays an important role in ceramide metabolism and can block apoptosis signal pathway which is mediated by ceramide. Recently, studies have demonstrated that overex-pression of GCS exists in various muhidrug resistant cancer cell lines and is related to drug resistant pheno-type. A possible connection between GCS and P-gp is also suggested. Moreover,the level of GCS can be down-regulated to increase tumor cells sensitivity by chemical inhibitor and RNA interference. Thus, inhibition of ac-tivity and expression of GCS is a new mechanism of reversing muhidrug resistance.
