Effects of continuous blood purification on inflammation and nutritional status in patients with sever sepsis
- VernacularTitle:连续性血液净化对重症脓毒症患者炎症及营养状态的影响
- Author:
Sirong WANG
;
Zhao HUANG
;
Wei SU
;
Yusheng CHEN
;
Jiyun LIU
- Publication Type:Journal Article
- Keywords:
Continuous blood purification;
Sepsis;
Prealbumin;
Insulin-like growth factor-1;
Inflammatory factor
- From:
Chinese Journal of Emergency Medicine
2008;17(10):1066-1070
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of continuous blood purification on inflammation and nutritional status in patients with sepsis, and to study relationship between inflammatory, malnutrition and illness. Method Forty-eight patients with severe sepsis were randomly divided into two groups: continuous renal replacement treat-ment (CRRT) group (n=27) and control group (n=21). The flowing biomarkers including albumin, preallbu-min, transfenin, insulin-like growth factor-1 (IGF-1), tumor necrosis factor (TNF-α) and C reactive protein (CRP) were determined before,and 1 week and 2 weeks after treatment. Results Compared with control group, levels of albumin, prealbumin and IGF-1 in treatment group increased significantly at 14 days after CRRT (P<0.05), and levels d CRP and TNF-α decreased significantly (P<0.05), resulted in increase in survival rate, shortened me-chanical ventilation time and decreased SOFA scores (P<0.05). The IGF-1 and prealbumin had a negative cor-relations with CRP and TNF-a in both groups (P<0.05). The survivors in both groups had significantly higher levels of IGF-1,prealbumin and TNF-α than the deads before trearment(P<0.05). Conclusions Continuous blood purification can effectively attenuate inflammation and improve nutritional status in patients with severe sep-sis.Maybe IGF-1 and prealbumin act as prognostic markers more sensitive in severe sepsis.
