Clinical diagnosis of 5 cases of pituitary stalk interruption syndrome
- VernacularTitle:五例垂体柄中断综合征的临床诊断
- Author:
Hongying YE
;
Qinghua LI
;
Xi WU
;
Yehong YANG
;
Jie WEN
;
Bin LU
;
Linuo ZHOU
;
Yiming LI
;
Yiming ZHOU
;
Zhenwei YAO
;
Xixing ZHU
;
Renming HU
- Publication Type:Journal Article
- Keywords:
Pituitary stalk interruption syndrome;
Growth hormone deficiency;
Hypopituitarism
- From:
Chinese Journal of Endocrinology and Metabolism
2008;24(5):483-485
- CountryChina
- Language:Chinese
-
Abstract:
Objective To raise the level of clinical diagnosis for the patients with pituitary stalk interruption syndrome (PSIS). Methods Five patients (4 males) with PSIS were retrospectively analyzed with respects to the clinical features, endocrine status and image characteristics. Magnetic resonance imaging (MRI) scan was performed at hypothalamic-pituitary region. Results The clinical manifestations of all patients consisted of growth retardation and delayed puberty without polyuria. Deficiency of multiple anterior pituitary hormones was revealed in all patients by the evaluation of endocrine status. The features of MRI included a lack of visible pituitary stalk, absence of posterior lobe hypersignal in the sella turcica and a hyperintense spot in the region of the thalamus opticus. Conclusion The clinical characteristics of patients with PSIS are growth retardation and delayed puberty. The evaluation of anterior pituitary function is necessary. The detection of an anatomical abnormality around hypothalamic-pituitary region by MRI is important diagnostic evidence.
