Changes of serum NT-proBNP concentration in patients with Graves' disease
- VernacularTitle:Graves病患者血清氨基端-脑钠肽前体水平的变化
- Author:
Liqun GU
;
Wei ZHU
;
Jianmin LIU
;
Fengying LI
;
Lin ZHAO
;
Tao JIANG
;
Minjia ZHANG
;
Yun LIU
;
Guang NING
;
Yongju ZHAO
- Publication Type:Journal Article
- Keywords:
Hyperthyroidism;
Graves' disease;
N-terminal-pro-B-type natriuretic peptide
- From:
Chinese Journal of Endocrinology and Metabolism
2008;24(5):505-508
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes of serum N-terminal-pro-B-type natriuretic peptide (NT-proBNP) concentration in patients with Graves' disease (GD) and its clinical significance. Methods Two hundred and sixty-nine patients with GD were enrolled in this study. Serum concentrations of thyroid hormones,TRAb, and NT-proBNP were measured. Results Serum NT-proBNP levels were positively associated with FT3(r=0.260, P<0.01), FT4(r=0.297,P<0.01) and heart rate (r=0.251, P<0.05) independent of age,sex and body mass index (BMI). The difference of serum NT-proBNP concentrations between newly-onset and treated patients existed (P<0.01) after the adjustment for thyroid hormone levels, age, sex and BMI. Serum FT4level exerted a significant impact on NT-proBNP level (P <0.01). Serum NT-proBNP increased even in patients with controlled thyroid function. Conclusion Serum NT-proBNP level in patients with GD increases with elevation of FT4 independent of sex, age and BMI. The measurement of serum NT-proBNP concentration appears to be helpful to monitor the alteration of vascular stiffness and fluid volume in GD patients, and may provide useful evidence for early intervention of cardiovascular disease induced by hyperthyroidism.
