Effect of preoperative transcatheter arterial chemoembolization on Inhibitor of apoptosis protein-Survivin and Survivin mRNA of hepatocellular carcinoma.
- VernacularTitle:经肝动脉化疗栓塞术对肝癌细胞生存素和增殖细胞核抗原的影响
- Author:
Ya GUO
;
Zhang WEN
;
Lequn LI
- Publication Type:Journal Article
- Keywords:
Hepatocelluar carcinoma;
Transcatheter arterial chemoembolizafion;
Survivin;
Prolifera-ting cell nuclear antigen
- From:
Clinical Medicine of China
2008;24(11):1106-1108
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of transcatheter arterial chemoembolizafion (TACE) on inhibitor apoptosis protein-Survivin, Survivin mRNA and proliferating cell nuclear antigen (PCNA). Methods Group A of hepatocelluar carcinoma with preoperative TACE (n = 26), group B of hepatocelluar carcinoma without any interven-tional therapy (n = 30) ,group C of Normal liver (n = 16) were divided. The expression of Survivin mRNA and the expression of Survivin and PCNA were detected. Result ①The positive Survivin mRNA expression in group A and the grey difference were lowere than that in group B (P < 0.05) ; ②The positive Survivin expression and the grey difference in group A were lower than that in group B (P < 0.05) ; ③The proliferating index (PI) of carcinoma tis-sure in group B was higher in group A and group C (P < 0.05 for each). Conclusion There is a high positive ex-pression of Survivin mRNA and Survivin, which may be decreased by TACE and then the proliferation of hepatocellu-lar carcinoma cell is surpressed.
