Changes and meaning of function and structure of diabetic rats' peripheral nerve
- VernacularTitle:糖尿病大鼠周围神经功能及结构的改变及意义
- Author:
Liping HAN
;
Demin YU
;
Yun XIE
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus/PP;
Peripheral nerves/IN/UL
- From:
Journal of Chinese Physician
2008;10(9):1203-1205
- CountryChina
- Language:Chinese
-
Abstract:
Objective The aim of this study is to undemtand the development of peripheral nerve injury on diabetes mellitus.Methods Diabetes was induced by STZ.We determined nerve conduction velocity,thermal pain threshold,morphoh)gy changes of sciatic nerve and quantitative analysis of sural nerve of diabetic model group and normal control group after 2 weeks,4 weeks,6 weeks,8 weeks,12 weeks respectively,and observed dynamically functional and morphologic changes of peripheral nerve of diabetic rats.Results After 2 weeks,diabetic rats showed that motor and sensory nerve conduction velocities slowed down and thermal pain threshold decreased.After 4 weeks.changes of pathology of sciatic nerve were observed.With the duration extending,the damages of nerve were aggravated gradually.Conclusions Neumpathy appeared in earlier stage on experimental diabetic rats and functional changes were preceded to morphologic changes.
