Matrix Metalloproteinase and Cerebral Ischemic Injury
- VernacularTitle:基质金属蛋白酶与缺血性脑损伤
- Author:
Hui LONG
;
Yonghong TANG
- Publication Type:Journal Article
- Keywords:
matrix metalloproteinase;
cerebral iachemia;
blood-brain barrier
- From:
International Journal of Cerebrovascular Diseases
2008;16(9):703-706
- CountryChina
- Language:Chinese
-
Abstract:
The studies of animal models have shown that the expression of matrix metalloprotease (MMP) is abnormal during cerebral ischemia/reperfusion,which indicating that it is associated with cerebral ischemia/reperfusion injury,especially MMP-2,MMP-3 and MMP-9 play the important roles in the pathogenesis of acute ischemic cerebrovascular disease.Understanding of the roles and expressions of MMP,the factors affecting its expression,and the studies and application of the related antibodies in cerebral ischemic/reperfusion injury may provide a new alternative for the early diagnosis,prevention and treatment of cerebral infarction.
