Expression of PTTG and its relationship with bFGF and MVD in esophageal carcinoma
- VernacularTitle:食管癌中PTTG蛋白表达及其与bFGF和微血管密度的关系
- Author:
Jialong GUO
;
Chengyi LIN
;
Shunqing ZUO
;
Jun ZHANG
;
Bingsheng XIE
- Publication Type:Journal Article
- Keywords:
Esophageal neoplasms;
Neoplasm proteins;
Pituitary neoplasms;
Fibroblast growth factor 2;
Capillaries
- From:
Journal of Chinese Physician
2008;10(9):1162-1165
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expressions of PTTG and bFGF proteins and their relationship with microvessels density(MVD)in esophageal carcinoma.Methods Immunohistochemical SP method was used to detect the expression of PTTG and bFGF proteins in 48 esophageal carcinoma tissues and the same para-cancerous tissues.MVD was evaluated by immunohistochemieal staining with antibody CD34.Results The positive rate of PTTG and bFGF was 68.8%(33/48)and 70.8%(34/48)respectively.Rate of PTTG protein expression in esophageal carcinoma tissues was significantly higher than that in para-cancerous tissues(8.3%and 12.5%,P＜0.05).The positive rate 0f PTTG,bFGF and MVD was correlated with lymph node metastasis and TNM stage.There was no relationship with age,sex,tumor size MVD(P＜0.05).Conclusion PTTG and bFGF are over-expressed in esophageal carcinoma.Increased PTTG may play an important role in carcinogenesis and development of esophageal carcinoma by promoting the expression of bFGF protein which may induce an angiogenesis.
