The protection of Atomolan on Ischemia-reperfnsion injury of the rat bile duct cells in liver transplantation
- VernacularTitle:还原型谷胱甘肽对大鼠肝移植中胆管细胞缺血再灌注损伤的保护作用
- Author:
Li LU
;
Junwei SHAO
;
Xun CAI
- Publication Type:Journal Article
- Keywords:
Glutathione/PD;
Reperfusion injury;
Bile ducts;
Liver transplantation
- From:
Journal of Chinese Physician
2008;10(9):1188-1190
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the mechanisms of ischemia-reperfasion(I/R)injury of the bile duet and the effect of Atomolan on Isehemia-reperfusion injury of the bile duct in liver transplantation.Methods Pathological changes of the bile duct cells in three groups of rat liver transplantation model were observed through light microscope.And the effective protection of Atomolan against ischemia-repeffusion injury was observed.Results In ischemia-reperfusion group,the injury of bile duct cells were more serious,the level of ALT,AST and γ-glutamyhransferase elevated higher,oxygen free radical generated more,and the apoptosis of bile duct ceils appeared more,compared with Atomolan pretreatment.Conclusion The injury in bile duct cells is more serious than that in hepatoeyte in I/R injury.Atomolan can provide effective protection against liver Ischemia-reperfusion injury.The mechanisms may be through depress the production of oxygen free radical and decrease the apoptosis of bile duct cells.
