Effectiveness and safety of combination therapy with domestic bezafibrate and fluvastatin in patients with combined hyperlipidemia
- VernacularTitle:国产苯扎贝特与氟伐他汀联合治疗混合型高脂血症的疗效与安全性
- Author:
Shuhua DI
;
Xiang TIAN
;
Peijun WANG
;
Yunxia WANG
;
Wei WANG
;
Libo ZHEN
- Publication Type:Journal Article
- Keywords:
Hyperlipidemia;
Atherosclerosis;
Cholesterol;
Triglyceride
- From:
Clinical Medicine of China
2008;24(11):1086-1088
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy and safety of combination therapy with domestic bezafibrate and fluvastatin in patients with combined hyperlipidemia. Methods 180 patients with combined hyperlipidemia were randomly divided into two groups. They were assigned to receive 40 mg fluvastatin (n = 90) or a combination of 400 mg bezafibrate and 40 mg fluvastatin (n = 90) for 24 weeks. Results After 24 weeks treatments, the serum TC, LDL-C levels were reduced (P <0.01) and HDL-C level was increased more significantly (P <0.05) in the combi-nation therapy group. Conclusion Combination therapy with bezafibrate (400 mg) and fluvastatin (40 rag) is more effective than fluvastatin(40 mg) monotherapy.
