Effect of long-term combination of Hydrochlorothiazide with Captopril or Spironolactone on serum high-sensitivity C-reactive protein in hypertension patients.
- VernacularTitle:氢氯噻嗪与螺内酯或卡托普利长期联用对高血压患者血清高敏C-反应蛋白水平的影响
- Author:
Shaomin SONG
;
Aijun XING
;
Dongqing LI
;
Haiyan ZHAO
;
Xin DU
;
Zhe HUANG
;
Shaoling WU
- Publication Type:Journal Article
- Keywords:
Hypertension;
Hydrochlorothiazide;
Captopril;
Spironolactone;
High-sensitivity C-re-active protein
- From:
Clinical Medicine of China
2008;24(11):1113-1116
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of combination of Hydrochlorothiaside (HCTZ) with Captopril or spironolactone on serum high-sensitivity C-reactive protein (hsCRP) in hypertension patients. Methods A multi-centre, random and parallel control study was applied in this study. Slight and moderate hypertension patiens were se-lected. The patients were treated with placebo for two weeks and HCTZ 12.5 mga day for 6 weeks,wbo were then randomly divided into HCTZ group(12.5 mg once a day), spironolactone group(HCTZ 12.5 mg once a day + Spi-ronolactone 20 rag once a day) and captopril group(HCTZ 12.5 mg once a day + Captopril 25 rag twice a day) . By the end of one-year follow up, HCTZ group was randomly added to Spironolactone group and Captopril group because combination therapy was superior to single medication,which was recognized. During the treatment, the patients were followed up once a month ,for monitoring blood pressure, and serum hsCRP level was measured every year. Follow-up last for 4 years. By the end of 4 years, the patients were divided into treatment group and control group in order to compare the changes of serum hsCRP levels. Results At the end of 4 years, the blood pressure and serum hsCRP level were significantly decreased as compared with baseline, and were statistically different from that of control group (P <0.05 or 0.01). Multi-factor analysis showed that pre-treatment systolic blood pressue and serum hsCRP level, post-treatment decrease value of systolic blood pressue and age were the major influencing factors for the de-crease of serum hsCRP level(P < 0.05 for each). Conclusion The long-term combinaion of HCTZ with Spironolactone or Captopril not only effectivley decreases blood pressure but also decreases serum hsCRP level. The decrease value of systolic blood pressure is the major factor for influencing serum hsCRP level.
