Relationship between prothrombotic state and cardiovescular disease In patients with impaired glucose toler-ance.
- VernacularTitle:糖耐量减低患者血栓前状态与心血管疾病危险性的关系
- Author:
Ai SONG
;
Mingzhao QIN
;
Yanling ZHAI
- Publication Type:Journal Article
- Keywords:
Impaired glucose tolerance;
Prethrombotic status;
Cardiovascular Disease;
vWF;
Pro-tein C System;
Plasminogen activator inhibitor 1
- From:
Clinical Medicine of China
2008;24(11):1121-1124
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the prothrombotic state ,the factors leading to this status,and its relation-ship with the risk of cardiovascular disease in impaired glueese tolerance (IGT) patients. Methods The patients were divided into 4 groups : ①20 control subjects, ②38 patients with IGT, ③20 patients with diabetes only,④31 with diabetes and coronary heart disease. The vWF, throbomodulin, protein C, protein S, plasminogen activator inhibi-tor 1 were measured by ELISA. Results ①)There was statistical difference between IGT and controls in vWF, activi-ty of PC and PAI-1 (P <0.01 ,respectively). ②There were different factors that probably lead to the prothrombotic status among patients with IGT and diabetes. ③There were statistical differences among IGT, diabetes and diabetes with coronary heart disease in vWF, activity of Protein C. There were statistical difference among IGT , diabetes and diabetes with Coronary heart disease in PAI-1 (P < 0.05,respectively). Conclusion ①There is the prothrombotic status in the patients with IGT, similarly to those with diabetes.② IGT has the similar prethrombotic status as diabe-tes, So IGT could be considered as the predromal stage of diabetes, because of some continuity in the progress. Mean-while,it still has some different specialties. ③The abnormality of the system of endothelium, anti-coagulation and fi-brolysis in the patients of IGT is similar to those with diabetes. These variations might have the similar risk of cardio-vascular disease with the diabetes.
