Transcription factor AP-2 and its effect on cancer
- VernacularTitle:转录因子AP-2及其在肿瘤中作用机制
- Author:
Lihui ZOU
- Publication Type:Journal Article
- Keywords:
Transcription factor;
AP-2;
Neoplasms
- From:
Journal of International Oncology
2008;35(10):723-726
- CountryChina
- Language:Chinese
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Abstract:
AP-2,a nuclear transcription factor family,always binds to a typical DNA sequence in the dimer way,thus AP-2 can regulates the expression of many other genes and participate in the growth and devel-opment, apoptosis and many other physiological processes. Under pathological conditions, AP-2 also plays an im-portant role in tumor genesis and development by influencing cell proliferation, differentiation, cell cycle regula-tion and apoptosis. Recent years,many researchers want to find new therapeutic strategies that target AP-2 in a series of human cancers.
