Research advances in regulation of hypoxia-inducible factor-1 by camptothecin compounds
- VernacularTitle:喜树碱类化合物调控缺氧诱导因子-1的研究进展
- Author:
Ning ZHANG
- Publication Type:Journal Article
- Keywords:
Camptothecin;
Neoplasms;
Hypoxia-inducible factor 1
- From:
Journal of International Oncology
2008;35(10):729-731
- CountryChina
- Language:Chinese
-
Abstract:
Hypoxia- inducible factor-1 ( HIF-1) promotes tumor deterioration, invasion and metasta-sis. Treatment targeting the HIF-1 signal pathway is becoming a hot research. In addition to uniquely selective inhibition of topoisomerase Ⅰ(Topo Ⅰ) ,the recent studies show that camptothecin compounds can regulate the activity of HIF-1 through decreasing HIF-1 protein translation and have been classified as a non-selective chemical inhibitor of HIF-1.
