Nerve growth factor and its receptors in tumors of nervous system
- VernacularTitle:神经生长因子及其受体与神经系统肿瘤的关系
- Author:
Yong YANG
- Publication Type:Journal Article
- Keywords:
Nerve growth factor;
Receptors,nerve growth factor;
Neoplasms,neuroepithelial
- From:
Journal of International Oncology
2008;35(10):735-738
- CountryChina
- Language:Chinese
-
Abstract:
Nerve growth factor (NGF) and its high affinity receptor tyrosine kinase (TrkA)are indis-pensable for the development of nervous system. Latest researches reveal that over-expression of NGF and TrkA is related to better outcome in neuroblastoma and medulloblastoma. While in glioma, the over-expression and nuclear translocation of NGF and TrkA are indicators of malignant degree. Study of the expression and sub-cel-lular cocalization of NGF and TrkA can provide new way for the diagnosis and therapy of nervous system tumors.
