Research advances of chemokine CCL21
- VernacularTitle:趋化因子CCL21的研究进展
- Author:
Ting GONG
- Publication Type:Journal Article
- Keywords:
Chemokines,CC;
Neoplasms;
Autoimmunity
- From:
Journal of International Oncology
2008;35(10):744-747
- CountryChina
- Language:Chinese
-
Abstract:
CCL21 is originally reported as a CC chemokine mainly expressed in secondary lymphoid tissues. CCL21 can dictate lymphocytes homing in the flow environment,where T cells use integrins stimulated by CCL21 to arrest on endothelial cells,and can act as a chemoattractant for T cells,B cells,mature dentritic cells and natural killer cells strongly. CCL21 can collect activated effector cells and keep them around the tumor. It is also a pivotal molecule for priming T cell responses. Therefore,CCL21 plays a potential role in anti-tumor therapy, and its high expression is responsible for many immune diseases.
