CDX2 gene in development of intestinal type gastric cancer
- VernacularTitle:CDX2基因在肠型胃癌发展过程中的研究进展
- Author:
Mengzhen JIANG
- Publication Type:Journal Article
- Keywords:
Caudal-related homeobox transcription factor 2;
Intestinal metaplasia;
Stomach neoplasms
- From:
Journal of International Oncology
2008;35(10):777-779
- CountryChina
- Language:Chinese
-
Abstract:
CDX2 plays an important role in the development, maintaining shape, structural characteristics of intestinal epithelial cells. Intestinal type gastric cancer is thought to develop a multi-step and multiphase process from normal gastric mucosa,intestinal metaplusia and dysplasia, ultimately to gastric cancer. So far, more and more studies have found that the abnormal expression of CDX2 gene plays an important role in development of intestinal metaplasia, dysplasia and intestinal carcinoma.
