Loss expression of FHIT closely correlated with clinicopathological features and post-resectional survival of gallbladder carcinoma
- VernacularTitle:抑癌基因FHIT表达缺失与胆囊癌病理特征及预后的关系
- Author:
Weidong CHEN
;
Yong MA
;
Hua ZHAO
;
Tiegang LI
- Publication Type:Journal Article
- Keywords:
Genes,tumor suppressor;
Histidine;
Gallbladder neoplasms;
Prognosis
- From:
Journal of Chinese Physician
2008;10(9):1159-1161
- CountryChina
- Language:Chinese
-
Abstract:
Objective We aimed to explore the expression of FHIT and investigate its correlation with clinicopathological features and prognosis of gallbladder carcinoma.Method Immunohistoehemieal detection of FHIT was performed on samples from 43 gallbladder carcinoma and 43 cholecystitis,and 2 years follow up was performed.Result FHIT protein was overexpressed in eholecystitis(x2=31.74,P=0.000).The overexpression was significantly related to differentiation and Nevin staging of gallbladder carcinoma(x2=4.47,P=0.035;x2=8.33,P=0.015);(rs=-0.56,P=0.031;rs=-0.68,P=0.014).Log-rank test showed that overexpression of FHIT had a good prognosis(x2=4.11,P=0.042).Cox analysis showed that expression of FHIT was all independent prognostic marker for postresectional survival of gallbladder carcinoma(RR:2.89,95%CI[2.46-3.32]).Conclusion Loss expression of FHIT closely correlated with clinicopathological features of gallbladder carcinoma.The expression of FHIT was an independent prognostic marker for post-resectional survival of gallbladder carcinoma.
