Therapeutic effect of pamidronate combined with chemotherapy on bone metastases cancer
- VernacularTitle:帕米膦酸二钠联合化疗治疗骨转移癌临床观察
- Author:
Junli LIU
- Publication Type:Journal Article
- Keywords:
Bone neoplasms;
Drug therapy,combination;
Pamidronate
- From:
Chinese Journal of Primary Medicine and Pharmacy
2008;15(10):1595-1596
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the curative effect and adverse drug reactions of pamidronate combination with chemotherapy in treatment of bone metastatic cancer. Methods 42 cases of cancer patients with bone metastasis are divided into two groups,20 patients in one group are treated with pamidronate only( pamidronate group) ,22 pa-tients in the other group are treated with pamldrunate combination with chemotherapy( combination group). Combined chemotherapy regiments in combination group are:NP regiment in non-small cell lung cancer,CAF regiment in mam-mary carcinoma,FAM regiment in prostate cancer. Results The effective rate of analgesia in pamidronate group is 65% ,combination group is 90.9%. There is statistically significant difference between two groups(X2=4.17 ,P<0.05). There is no statistically significant difference in improvement of Kap grade and ability in activity between two groups(P>0.05). Conclusion Pamidronate combination with chemotherapy is an effective curative method for bone metastasis of advanced malignant tumor. Pamidronate only is a satisfactory curative method for advanced malignant tumor patients that can not endure chemotherapy.
