Correlation between eystathionine βsynthase T833C gene polymorphism and ischemic cerebral vascular disease
- VernacularTitle:胱硫醚β合酶基因T833C多态及血浆同型半胱氨酸水平与缺血性脑血管病的相关性
- Author:
Yuqiang SONG
;
Fangqing LIU
;
Chen ZHANG
- Publication Type:Journal Article
- Keywords:
Brain ischemia;
Cerebrovaseular accident;
Homocysteine;
Cystathionine beto-synthase;
Polymorphism,genetic
- From:
Chinese Journal of Neurology
2008;41(11):731-733
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between cystathionine β-synthase (CBS) T833C gene polymorphism and the plasma homocysteine (Hey) levels in patients with ischemic cerebral vascular disease(ICVD). Methods Three hundred and sixty patients with ICVD and 210 control subjects were enrolled. The T833C polymorphism of CBS gene was analyzed by the amplification refractory mutation system (ARMS). Plasma Hey levels were measured by high performance liquid chromatography-fluorescence detection(HPLC-FD). Results Plasma Hey levels in the ICVD group ((17.6±4.8) μmol/L) were higher than those in control group ((13.3±4.3) μmol/L, t = 10.716, P< 0.05) . There were no differences in genotype frequencies and allele frequencies between the ICVD group and contral group (χ2 = 0.785, 0.941 ,P>0.05). Plasma Hey levels in CC genotype or TC genotype were higher than those in TT genotype (F = 6.56, P< 0.05). Condusions High plasma Hey level is an independent risk factor of ICVD,but CBS T833C polymorphism may not associated with ICVD.
