Progress in research of polyamidoamine dendrimers as gene carriers
- VernacularTitle:聚酰胺-胺型纳米载体在基因治疗中的研究进展
- Author:
Zhijun HUANG
;
Bin YI
- Publication Type:Journal Article
- Keywords:
Polyamidoamine dendrimers;
Carrier;
Gene therapy
- From:
International Journal of Biomedical Engineering
2008;31(5):308-311
- CountryChina
- Language:Chinese
-
Abstract:
Polyamidoamine (PAMAM) dendrimers is considered a better genetic carrier for its ability to form with DNA a nano-sized polyelectrolyte complex of high stability and dissolubility. The mechanism of PAMAMmediated gene endocytosis has been fairly clear and the researches in vitro have confirmed that PAMAM had high transfection efficiency and low cytotoxicity. The researches in vivo have further confirmed that PAMAM had a potential application foreground in the field of gene therapy including in the prevention and treatment of ewing's sarcoma and pulmonary fibrosis, in heart transplantation, and in the preparation of falciparum malaria vaccine.
