Progress in the studies on the induction of pluripotent stem cells
- VernacularTitle:诱导多能干细胞的研究进展
- Author:
Xuexia LIU
;
Jianyuan LI
- Publication Type:Journal Article
- Keywords:
Tissue engineering;
Embryonic stem cells;
Induced pluripotent stem cells
- From:
International Journal of Biomedical Engineering
2008;31(5):294-297
- CountryChina
- Language:Chinese
-
Abstract:
The main objective of human tissue engineering is to grow cells in vivo to promote proliferation and differentiation and replace, repair, maintain, or enhance the functions of impaired tissues and organs. Embryonic stem cells are the first selected seed cells in tissue engineering due to their unlimited proliferation capability and the potential to differentiate into different kinds of cells. In this review will give a sketch of recent advances in the preparation of induced pluripotent stem cells, which can differentiate into many other kinds of cells, by applying different transcript factors including Oct3/4, Sox2, c-myc, Klf4, Nanog and LIN28 to somatic ceils via retroviral transduction.
