Expression of TR6 and survivin gene in the tissue of cardiac cancer and its clinical significance
- VernacularTitle:贲门癌TR6和survivin基因表达及其临床意义
- Author:
Zhuhong LIU
;
Shaohu CHEN
;
Youjia CHEN
;
Wenbin XU
;
Lixia XIE
;
Jinhui SHEN
;
Yangpeng NI
- Publication Type:Journal Article
- Keywords:
Stomach neoplasms/GE;
Receptors,tumor necrosis factor;
Microtubule-aasociated proteins;
Cardia
- From:
Journal of Chinese Physician
2008;10(10):1336-1338
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical significance of expression of DcR3/TR6 gene in the tissue of cardiac cancer and its correlation with survivin gene expression, Methods Two-step immnaohistochemistry technology was adopted to detect the expression of TR6 and survivin gene in 66 cases of cardiac cancer, none of the patients received prior chemotherapy. Results The positive expression rate of TR6 and survivin genes in cardiac cancer was 54.5% and 62.1% , respectively. The expression of TR6 was correlated with histology type,clinical stage and lymph node metastasis of cardiac cancer ( P<0.05 ). The positive expression rate of TR6 in cases that cardiac cancer with survivin expressed was significant higher than those without surviving expressed (χ2=15.145, P<0.01 ). Conclusions The expres-sion of TR6 and survivin can be regarded as valuable indicators for the diagnosis and prognosis of cardiac cancer.
